cAMP NOMAD ADRA2A Receptor Cell Line

Description cAMP NOMAD Cells are cell lines stably co-expressing tag-free GPCRs and cAMP Nomad Biosensor to monitor G-protein modulation by cAMP release. Each vial of cAMP NOMAD ADRA2A Receptor Cell Line contains U2OS cells stably expressing the following constructs: Human α2A-adrenoceptor with no tag cAMP Nomad Biosensor (Green Fluorescence) cAMP NOMAD ADRA2A Receptor Cell Line allows to assay compounds analyzing the G-Protein signaling pathway by cAMP involving receptor activation. When an agonist binds to ADRA2A, a G protein is activated. This activation triggers a cellular response mediated by changes in cAMP levels. The ADRA2A Receptor Cell Line leads to an increase in green fluorescence intensity of the cAMP biosensor. Thus, receptor activity can be easily quantified in living cells in a dose-dependent manner by measuring fluorescence emission with a microplate reader.